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Downs, of Menomonee Falls, researches the process of normakl egg maturationin mammals, specifically the metabolic pathwayzs that help regulate development of oocytes — unfertilized egg cells. Understandingf how these metabolic pathways regulate normap maturation is important because abnormalitiesx in the process can lead to abnormalp developmentof eggs, manifestexd in chromosomal irregularities such as Down syndrome. Whilde Downs said he focuses mainlt on the most scientific level of understandingegg maturation, he is inspirex by the applications of his research.
In addition to better understandiny causes ofDown syndrome, his research applications include optimizing fertility treatments and diabetes treatmentf and prevention. His research also has been appliedf to maximizing fertility efficiency in domestic livestock by perfecting invitro “There’s nothing like coming into the lab and findintg out that the data you’ve collected matches what you hypothesizedx would happen,” he said in a statement. “It’ds that excitement of discoveryy that keeps me coming back for Most recently, Downs’ work has focused on the effectds of a stress-response proteijn on regulating oocyte maturation in mice.
Results of thesse studies could show a connectiombetween physical, chemical and metabolic stress and abnormalitied in development. Downs was selected for the awardby Marquette’as Committee on Research and received
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